粪肠球菌感染小鼠的组织病理学观察

粪肠球菌感染小鼠的组织病理学观察(5700字)
摘 要:粪肠球菌是动物肠道正常菌群,但近年来的研究表明，该菌早已经成为院内感染的重要机会致病菌之一，在兽医领域，粪肠球菌能引起猪，牛，羊，禽等动物发病而引起高度关注。本实验对实验小鼠通过腹腔注射半数致死量为9.3×1010个活菌数的粪肠球菌菌液，待小鼠自然死亡后，取小鼠的脏器做石蜡病理切片。从微观病理变化发现小鼠各脏器细胞均有不同程度的变性，坏死。脏器血管均有充血，淤血，中性粒细胞和淋巴细胞增多。说明粪肠球菌能侵害小鼠的各主要脏器，同时引起小鼠的免疫反应。
关键词:粪肠球菌  感染  小鼠

Enterococcus faecalis pathological changes of infected mice
Abstract:Enterococcus faecalis nearly normal intestinal flora of animals, but years of research show that the bacteria had already become an important opportunistic pathogen of nosocomial infection, one in the veterinary field, Enterococcus faecalis can cause pigs, cattle, sheep, poultry, etc. animal disease caused great concern. The experiment on mice by intraperitoneal injection of the median lethal dose was 9.3×1010  the number of viable bacterium Enterococcus faecalis, until natural death in mice after the organs of mice paraffin biopsy. Microscopic pathological changes from the organs of mice cells were found in different degrees of degeneration and necrosis. Vascular organs have congestion, congestion, neutrophils and lymphocytes increased. Description of Enterococcus faecalis to the major organs of mice against the same time, the immune response in mice.