几种镇痛药物对动物镇痛作用的实验研究
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密 惠 保
几种镇痛药物对动物镇痛作用的实验研究(7100字)
摘 要：［目的］为了探索不同剂量蚯蚓提取物对小鼠的镇痛效果的影响。［方法］选取50只小鼠随机分成5组（1个对照组4个试验组），每日分别对各试验组灌服试验药物（醋制延胡索、蚯蚓提取物原液、蚯蚓提取物5倍稀释液、蚯蚓提取物10倍稀释液），连续服药21日后对小鼠利用热板法和扭体法测定各种药物的镇痛效果；另25只大鼠随机分成5组（1个对照组和4个试验组），制备大鼠离体膈神经-膈肌标本收缩实验，实验药物为（醋制延胡索、蚯蚓提取物原液、蚯蚓提取物5倍稀释液、蚯蚓提取物10倍稀释液），应用BL-420生物机能实验系统测神经兴奋波形图。［结果］蚯蚓提取物具有良好的镇痛活性。
关键词：蚯蚓提取物；热板法；扭体法；镇痛；大鼠膈神经-膈肌离体试验。
Experimental study of analgesic effect on animals several drugs
Abstract: [Objective]Exploring the influence of earthworm extract's anagelsic effect to animal. [Methods]Select 50 mices randomly divided into 5 groups(one control and 4 test groups), Day of each test group were fed experimental drugs,respectively (Vinegar Corydalis, liquid extract of earthworms, five times earthworm diluted extract,ten times dilution of earthworm extract) ,Continuous use of drugs in mice 21 days of hot plate and writhing method analgesic effect of various drugs; Another 25 rats were randomly divided into 5 groups (one control and 4 test groups) Preparation of isolated rat phrenic nerve - diaphragm contraction of experimental specimens, Experimental drugs (Vinegar Corydalis, liquid extract of earthworms, five times earthworm diluted extract,ten times dilution of earthworm extract) , Application of BL-420 Biological Experimental System waveforms measured nerve excitability.[Results] Earthworm extract with good analgesic activity.
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Key words: Earthworm extracts; Tetrahydropalmatine; Hot plate; Writhing test; analgesic; Rat phrenic nerve - diaphragm in vitro test.
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