小鼠感染PCV-2的病理学研究

小鼠感染PCV-2的病理学研究(5800字)
摘  要：猪圆环病毒2 型（Porcine circovirus type 2，PCV2）隶属于圆环病毒科圆环病毒属，是断奶仔猪多系统衰竭综合征的主要致病原，给我国乃至世界的养猪业造成了巨大损失。此实验用PCV2 感染小鼠，分为实验组18只和对照组6只，并统一于21天后剖杀，从心、肝、脾、肺、肾、脑、淋巴结多方面观察病理学变化及组织学变化。剖检可见到多器官组织的病理损伤，全身淋巴结肿大，切面凸起，灰白色。肺部散布着灰褐色的病灶，表现为多灶性间质性肺炎。肺门淋巴结出现局灶性坏死以及周围出血。肝脏、肾脏可见到花斑状外表和黄疸，有的脾脏萎缩。组织学病理变化最大的是淋巴结，淋巴结尚见有局灶性坏死区以及明显的充血；肺呈支气管周围炎及间质性肺炎变化，肺泡壁Ê 型细胞肿胀，变圆，巨噬细胞数量增多，继发细菌性感染的病例在支气管内尚见有明显的嗜中性粒细胞浸润；肝细胞变性坏死，尤其在肝小叶区，见多核聚集现象；肾小管不同程度萎缩、坏死，间质明显水肿。
关键词：小鼠；PCV2；剖检病变

Pathology Research Of PCV2 Infected Mice
Abstract: Porcine circovirus type 2 (Porcine circovirus type 2, PCV2) belongs to Circoviridae Circovirus genus, is a major pathogens of post-weaning multisystemic wasting syndrome, which caused tremendous loss in hog industry in China or even the world. The experiment operated by infected mice by PCV2, which divided experimental group of 18 rats and control group of 6 rats. and all killed after 21 days .We can observe the various pathological changes and histological changes from the heart, liver, spleen, lung, kidney, brain, lymph nodes. It turns out that ethological damage in multiple organs from necropsy, lymphadenopathy, which facers raised, off-white. Lung dotted with brown and lesions which showed multifocal interstitial pneumonia. Hilar lymph nodded with focal necrosis and occurred around the bleeding. Liver, kidneys can see flowers porphyritic appearance, jaundice, and some spleen atrophy. The biggest tissue pathology is lymph nodes which can see a clear focal necrosis and congestion; lung inflammation and bronchi are changed in interstitial pneumonia, alveolar wall E cell swelling, rounded, increased in the number of macrophages and secondary bacterial infections in the end bronchial still see a significant Europhile infiltration; liver cell had a degeneration and necrosis, especially in the lobular area, we can see the multi-core aggregation; Beside tubular atrophied in various degrees, necrosis, interstitial obvious edema.

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